I switched from Chrome to Firefox on my Mac desktop and the memory usage was cut in half at least. I only use it on my Linux notebook, so I have no idea about the memory usage difference there, but there was an unquestionable difference on the Mac. It has 16 gb of ram and is from 7 years ago, so it was before the M-chips and their ram hunger and still gave me memory warnings.

Now I never have memory issues on it. All it took was switching to Firefox.

So it definitely makes a difference on some systems.