If you have a general understanding of the characters, you could jump in and have fun. It’d definitely be worth it to see the first two Deadpool movies and Logan first for better context, but I’d say it’s easy to follow. From the Marvel side, the Loki series provides background on a key organization in the movie, but don’t sweat it if you haven’t seen that either (But it definitely is good)
If you have a general understanding of the characters, you could jump in and have fun. It’d definitely be worth it to see the first two Deadpool movies and Logan first for better context, but I’d say it’s easy to follow. From the Marvel side, the Loki series provides background on a key organization in the movie, but don’t sweat it if you haven’t seen that either (But it definitely is good)