Me personally? I’ve become much less tolerant of sexist humor. Back in the day, cracking a joke at women’s expense was pretty common when I was a teen. As I’ve matured and become aware to the horrific extent of toxicity and bigotry pervading all tiers of our individualistic society, I’ve come to see how exclusionarly and objectifying that sort of ‘humor’ really is, and I regret it deeply.
I worked for years with developmentally disabled adults. Saying that word even once was automatic termination.
The word does have medical/mechanical relevance but is so offensive nowadays that it’s worth not using it at all.