The word can have swearing but not genderisation which might be offensive (mother) nor allusions to sexual dominance (motherfucker). Nor, other possibly offensive connotations. It seems that the word is commonplace and people won’t stop using it, so an alternative to the word may be useful. But the problem with alternatives, is that people might not use them unless they carry a meaning that’s attention grabbing in some way, and when it comes to this word it needs to be able to be used in either a serious (non-funny) or comedic way.
I thought OP was looking for minced oaths that could be used in its place, and this is the first thing that came to mind for me. I use this one all the time because I try not to drop the big one around my five- and three-year-olds.