I see what you mean, but at the same time, there is a wealth of animation styles within Anime series too. Some as that popular anime style that most associate it with, others that are a lot more western cartoon influenced in their style.

I would argue that CGI, pixar, dreamworks, etc is far enough away. But the Simpsons is a traditional cartoon, and it likely wouldn’t be too difficult to find an anime that is stylistically similar within the massive archive.