Hundreds of thousands of U.S. patients are harmed or die each year because of diagnostic errors. Women and minorities are up to 30% more likely to be misdiagnosed than white men.

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In a study published Jan. 8 in JAMA Internal Medicine, researchers found that nearly 1 in 4 hospital patients who died or were transferred to intensive care had experienced a diagnostic error. Nearly 18% of misdiagnosed patients were harmed or died.

In all, an estimated 795,000 patients a year die or are permanently disabled because of misdiagnosis, according to a study published in July in the BMJ Quality & Safety periodical.

Some patients are at higher risk than others.

Women and racial and ethnic minorities are 20% to 30% more likely than white men to experience a misdiagnosis, said Dr. David Newman-Toker, a professor of neurology at Johns Hopkins School of Medicine and the lead author of the BMJ study. “That’s significant and inexcusable,” he said.

Researchers call misdiagnosis an urgent public health problem. The study found that rates of misdiagnosis range from 1.5% of heart attacks to 17.5% of strokes and 22.5% of lung cancers.