There is a well established association between silica inhalational exposure and autoimmune disease, particularly in the context of intense exposure. We will provide in this article an update overview of new sources of silica dust exposure, with evidences ...

There is a well established association between silica inhalational exposure and autoimmune disease, particularly in the context of intense exposure.

Silicosis increases susceptibility to autoimmune diseases. The newer industries of sand-blasting denim and engineered stone have been associated with alarmingly high rates of silicosis

A multinational registry has documented diagnostic details related to autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune myositis, mixed connective tissue disease, psoriasis, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis among individuals with silicosis.

Autoimmune disorders are induced by various environmental and occupational substances. Silica exposure is recognized as a causative factor for autoimmune disorders, with well established connections to conditions such as pulmonary fibrosis (silicosis), rheumatoid arthritis (Caplan’s syndrome), systemic sclerosis, systemic lupus erythematosus, and ANCA-related vasculitis/nephritis.

Understanding a person’s occupational history to silica is an essential aspect for evaluating potential environmental factors that may contribute to autoimmune diseases.