Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
elifesciences.org
There is substantial individual variation in behavioral and neural responses to acute ketamine administration in healthy controls, which emphasises the need for personalized approaches when harnessing ketamine as a treatment for depression.

This paper presents a valuable investigation of the acute effects of ketamine in healthy volunteers using rating scale-based behavioral and resting-state fMRI-based neural measures. It provides solid evidence of inter-individual variability in responses to ketamine along with associations to relevant gene expression markers (somatostatin, parvalbumin) in the brain. >