Summary for the lazy, by a lazy:

Gastroparesis is when the muscles that flex to empty your stomach contents into your intestines do so considerably later than when they normally would, or sometimes not at all.

This means that your stomach can empty far more acid into your intestines than normal, and/or a large lump of semidigested food is attempted to be passed to the intestines all a once. (This mass is apparently called a bezoar, hooray new word!)

Users of GPL-1 drugs (the class of drugs in question) can experience nausea, vomiting, abdominal pain, bloating, heartburn, and in extreme cases, severe dehydration, malnutrition and unintended weight loss.

If the blockage scenario from earlier, where a mass of food just accumulates in your stomach and is not passed, and actually blocks digestion entirely, this can be life threatening and require surgical intervention.

GLP-1 drugs are now, according to three recent preliminary studies, known to be a risk factor for gastroparesis.

Former users of Ozempic, Wegovy, Mounjaro, and Zepbound are now suing the makers of the drugs for gastroparesis (and presumably other negative health effects).

While one of the studies shows that 1% of those prescribed a GPL-1 drug develop gastroparesis compared to 0.4% of those not prescribes a GPL-1 drug developing gastroparesis, some former users continue to experience symptoms after discontinuing the drug.

Currently, GPL-1 drugs do not and are not required to list gastroparesis as a possible side effect, though they do list ‘intestinal blockage’ following an FDA mandate in fall of 2023.

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