Highlights
•3D genome architecture is preserved in a 52,000-year-old woolly mammoth sample
•PaleoHi-C makes it possible to assemble the woolly mammoth’s genome
•Chromatin compartments also persist, enabling study of mammoth gene expression
•We propose that dehydration led to a glass transition arresting molecular movement
We hypothesize that, shortly after this mammoth’s death, the sample spontaneously freeze-dried in the Siberian cold, leading to a glass transition that preserved subfossils of ancient chromosomes at nanometer scale.
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