Research from Radboud university medical center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory of innate immune cells operated independently.

Research from Radboud university medical center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory of innate immune cells operated independently.

This surprising connection opens up new possibilities for the treatment of various diseases. A mouse model shows that no immunosuppressive drugs are needed after an organ transplantation if this interaction between T cells and the innate immunity is temporarily blocked after the transplantation.

Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling

Highlights

•T cells modulate trained immunity induction in monocytes via CD40-TRAF6 signaling

•Blocking CD40-TRAF6 signaling inhibits trained immunity in monocytes in vitro

•SNPs in the proximity of CD40 associate with trained immunity responses in vivo

•Myeloid-specific CD40-TRAF6 inhibition prolongs allograft survival in vivo

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01015-5