Summary

New research links loneliness to ill health through elevated levels of proteins associated with inflammation, immune responses, and metabolic processes.

Using data from over 42,000 UK Biobank participants, researchers found higher levels of 175 proteins in those reporting social isolation or loneliness, with many tied to cardiovascular disease, stroke, type 2 diabetes, and mortality.

The study identified five proteins influenced by loneliness that partly explain these health risks.

Experts highlight systemic inflammation and stress-related behaviors, such as alcohol use, as key factors and suggest societal focus on reducing loneliness for better health outcomes.