All the PC parts should be compatible on paper but if there is something standing out please let me know. Or if there is a better alternative that I am not aware of, I would love to hear your thoughts. Thanks!
PS. The 6750xt was $379 just yesterday :( Missed my window.
There are a few things to consider here. I would go with a beefier mother board with wifi and Bluetooth built in. Drop to DDR4. Consider a bigger power supply because if you upgrade anything, you probably will need it. Especially if you add more cooling fans. All in all you can do alot with this. But why two Hard Drives? I just run an M2 without much issue and I game a lot.