Part 3
Psychedelic as experience that when experienced, seems to help people profoundly more often than it harms people irreparably
Although working on many different parts and systems in the brain, some overlapping with serotonergic psychedelics, some not, the experience and its effects have been studied consistently for over 100
Experiences of Awe Mediate Ketamine’s Antidepressant Effects: Findings From a Randomized Controlled Trial in Treatment-Resistant Depression (Aepfelbacher, et al, 2024) https://pubmed.ncbi.nlm.nih.gov/38726038/
“ Ketamine infusion strongly induced heightened feelings of awe, and these experiences consistently mediated depression outcomes over a 1- to 30-day period, unlike general dissociative side effects. The specific awe-inspiring properties of ketamine may contribute to its antidepressant effects.”
Experiences of Awe Mediate Ketamine’s Antidepressant Effects: Findings From a Randomized Controlled Trial in Treatment-Resistant Depression (Aepfelbacher, et al, 2024) https://pubmed.ncbi.nlm.nih.gov/38726038/
“ Ketamine infusion strongly induced heightened feelings of awe, and these experiences consistently mediated depression outcomes over a 1- to 30-day period, unlike general dissociative side effects. The specific awe-inspiring properties of ketamine may contribute to its antidepressant effects.”