And for pregnant people. Which is why it’s great we ban vaping and all other nicotine for young children. But by the late teens, it’s not really more harmful than coffee or carbs or weed, to say nothing of alcohol.
But is it more harmful than inhaling all the other garbage in cigarettes? It becomes an issue of damage mitigation because no amount of laws are ever able to stop substance use. They often make the problem worse, too.
Of course not, cigarettes are nasty. But what I would like to understand is: are kids vaping way more nicotine now and getting every more addicted? You don’t get addicted to cigarettes per se, but to nicotine.
And flavoured cigarettes were banned in many places and helped stop some young people from starting to smoke.
I remember the flavor ban and thought to myself that it was going to be good to do so that it would not be as attractive to kids. The article is implying that the flavor ban did not stop kids from vaping. In fact, the ban corresponded with a slight increase in kids vaping, which does not make sense to me.
Of course, correlation does not mean causation and the two facts may not be directly related. Maybe kids heard all the talk of the ban and that served as advertising to get them to start. More studies are needed.
When doctors ask if you smoke, they primarily care if you smoke things containing nicotine. Iirc, that’s the cause of the smoking related heart disease risk (among other health concerns).
The vast, vast majority of the problems associated with smoking is from the carcinogens in tobacco. Nicotine can cause issues, but only on the order of caffeine. It’s a massive difference in scale.
Is it the fins that use snuss that is showing to be much less dangerous? Basically nicotine by itself doesn’t appear to be showing anywhere near the health issue that smoking does. But idk in this world of corporate sponsored studies maybe I’ve been lied to.
I’d actually be happy to, but it requires some deep diving into studies. Most studies will have a headline that says something like “using nicotine is just as bad as vaping!!!” but the data almost never actually supports the conclusion. It’s terrible, terrible science and it’s one of the worst examples of systemic problems with bad science. There’s a clear cultural push to villify nicotine.
Then those conclusions are reported by other meta studies etc etc
I’m not saying to get your data from sketchy YouTube videos or anything, just do a critical peer analysis of the actual data from various studies. I’ll do it for you. I’ve dived into it before and I’ll be glad to do so again, but I won’t have time until the weekend. It’ll take a couple of hours. I’m gonna favorite your comment so I can get back to it.
Ok let me just lead with, how the FUCK is there no way to sort inbox replies by saved? Isn’t that the whole damn point?
Alright, here we go. Gonna have to split this into multiple posts. Here’s the first.
Let’s start, like any good research, with the wikipedia article on nicotine. The intro specifically notes how it’s NOT a carcinogen, and mentions a few extremely mild or disputed adverse effects, but doesn’t go too much into it.
Later in the article, it says
Nicotine is classified as a poison. However, at doses used by consumers, it presents little if any immediate hazard to the user.
Which should be a good indicator that the common ideas about nicotine being harmful are wrong. But, fair enough wikipedia is not a stringent source and shouldn’t be taken at face value, so let’s dive deeper.
Here’s a search for “nicotine harmful effects”. Let’s separate them into broadly 3 categories of results. There’s stuff like this heart.org result, which exclusively talk about “smoking and nicotine”. These types of articles are dangerous in and of themselves because they require a level of critical thinking to separate out “smoking” and “nicotine”. A lot of anti-vaping hit pieces have a top-level title talking about nicotine, but then the body of the article references negative effects that are exclusive to smoking. Here’s one such hit piece, run by a dystopian-sounding group called the “Truth Initiative” which should immediately make anyone suspicious of their goals. Note the article is under topic “harmful effects of tobacco”, subtopic “nicotine addiction”.
Second, we have government pages like the CDC which very clearly state
No tobacco products, including e-cigarettes, are safe.
I’ll spend the next few paragraphs pointing out how this is simply declared to be so by governments, with no sources whatsoever to back it up. It’s a self-referential kind of contagion of an idea being spread from government office to government office, officially by policy and unofficially by encouragement, peer pressure, and referencing other authoritative offices.
Many government pages actually have no sources listed at all; their pages are literally just political opinion dressed up in an authoritative government voice. I gave the example of the CDC because it actually does have sources: this one which just links to the home page of a different CDC department, and this one which links to an office that works on tobacco, not e-cigarette, dangers.
If you dig a bit deeper on the first page, you find this factsheet for states. Let’s take California as an example. Under the section “Public Health Response to Tobacco Use in California”, it proudly lists these accomplishments:
Secondhand smoke causes stroke, lung cancer, and coronary heart disease in adults; in addition, it increases risks for sudden infant death syndrome, middle-ear disease, respiratory symptoms, and slows lung growth in children. In 2016, California enacted multiple tobacco control laws as part of a special legislative session in the state. The new laws: closed loopholes in the state’s smoke-free law making hotel lobbies, small businesses, and break rooms smoke-free; defined e-cigarettes as a tobacco product; prohibited vaping wherever smoking is also not allowed; required all K-12 public schools to be tobacco free; raised tobacco retail licensure fees; and increased the legal age of sale of tobacco from 18 to 21. These policies will further protect youth and adults in California from secondhand smoke exposure and e-cigarette vapor in public places. Increasing the age of sales for tobacco to 21 and requiring all public schools to be tobacco-free will protect youth from exposure to these products and further change social norms in California about the acceptability of smoking. The Institute of Medicine projects that if the age of sale were raised now to 21 nationwide, then there would be approximately 223,000 fewer premature deaths, 50,000 fewer deaths from lung cancer, and 4.2 million fewer years of life lost for those born between 2000 and 2019.
Emphasis mine. Note the lumping together. Again, vaping is just declared, by fiat, to be equally bad as smoking. DEFINED e-cigarettes as a tobacco product.
So far we’ve talked about two of the 3 categories, non-profits and government agencies, both of whom say “nicotine bad” with no supporting data at all. So let’s get to the 3rd category: the actual fucking data.
Let’s look at one of the top results, from the NIH. The introduction starts with the sentence “Tobacco is the leading cause of preventable cancers.” Oof, not a good sign. But let’s continue.
Nicotine is well known to have serious systemic side effects in addition to being highly addictive. It adversely affects the heart, reproductive system, lung, kidney etc. Many studies have consistently demonstrated its carcinogenic potential.
Oh yeah? Let’s look at these studies.
Jensen et al, “Mechanisms for nicotine in the development and progression of gastrointestinal cancers”. This is another “study of studies”. Note we’re two layers deep here and still haven’t seen the actual data. The Jensen study focuses on the mechanisms that nicotine can cause cancer, but doesn’t disclose the crucial data about dosage and likelihood. But it does reference other studies. Let’s go deeper.
.
1a) Tun et al, “Tobacco use and cancer: an epidemiologic perspective for geneticists”. The Jensen article claims, “There is increasing evidence that nicotine and its derivatives activate and promote key processes in the carcinogenesis of GI cancers.” and references the Tun study. The Tun study states in the Abstract:
1b) In the section “Role of nicotine in esophageal and oral cancer”, the Jensen study references several different studies.
1b1)Arredondo et al, “A Receptor-Mediated Mechanism of Nicotine Toxicity in Oral Keratinocytes”: studied possible carcinogenic effects on the skin, mouth, and digestive tract. Studied by incubating human cells in a culture of nicotine, and also by exposing rats to a constant exposure of pure nicotine in water (as well as a different group exposed to cigarette smoke). This is a constant, 24/7 exposure to the equivalent level of nicotine from secondhand smoke from 1 cigarette / 8 minutes for three weeks. As the Materials and Methods section says, “This concentration of sidestream cigarette smoke was selected because it represents a high ambient level that individuals could encounter at home or in other settings where smoking occurs”. It’s a study that tests the secondhand smoke affects of ambient nicotine. The incubated cells were exposed to “10 μM of pure Nic” which is the equivalent of each tiny little cell culture puffing on two cigarettes (10 kilamoles = 1.6224 mg of nic, average cigarette contains about 8.4 mg of nic, source) Best data I can find is that a pack-a-day smoker and a high-concentrate vape user consume about the same levels of nicotine as each other. But vape clouds produce almost undetectable amounts of “secondhand nicotine”, so it’s not directly comparable. The rats who drank the pure nicotine also were given doses of 10 μM (again, equal to about 2 cigarettes worth) constantly for 3 weeks.
Basically, way more nicotine than the typical vaper will encounter, only generates some indicators for some cells to possibly malform. It’s demonstration that at extremely high concentrations, nicotine can generate a mechanism for cancer.
1c2) Kita et al, “Expression of uPAR mRNA in peripheral blood is a favourite marker for metastasis in gastric cancer cases”: this study doesn’t directly deal with nicotine, but with a certain marker whose prevalence could help metastasize gastric cancers. The reasoning of the Jensen study is that since nicotine increases the prevalence of this marker, nicotine use could contribute to carcinogenic effects. (funny enough the Jensen study then cites another paywalled study whose abstract, at least, does not even mention this particular marker)
1d2) Wong et al (same Wong), “Nicotine Promotes Colon Tumor Growth and Angiogenesis through β-Adrenergic Activation”: similar line of investigation. Mice were implanted with tumors, and then fed nicotine-laden water at different concentrations. More nicotine --> more adrenaline --> bigger tumors. Note: the amount of nicotine used was supposedly consistent with previous studies showing concentrations of nicotine in typical smokers, but since mice drink about 5.8 ml of water a day and these guys were delivering either 50 or 200 mg of nicotine per ml, that’s 290 or 1160 mg of nicotine–the equivalent of either six or 24 cigarettes per day…FOR A MOUSE. In fact, the study they linked to support their claim that they’re using levels of nicotine consistent with typical smokers, while paywalled, has an excellent abstract stating that a nicotine patch of 44 mg a DAY was equivalent to the nicotine consumption of a >30 cigs/day smoker. That’s a lot lower than the 8.4mg noted in my source above in 1b1, which should suggest 252 mg of nicotine, but either way, it’s an absurd dose to give to a mouse.
So like, they took the high end of that study they referenced, increased it a little, used that as the low end of their study, made their high end 4 times that, and then gave that amount to a fucking mouse injected with a human tumor. And then did it again, 5 more times a day. And then said that “mimicked the daily intakes of cigarettes in smokers”. HAH.
1e) Pancreatic cancer. Most of this deals with models and potential modes of carcinogenity from nicotine, not hard data. But we can breadcrumb our way from the models to actual studies.
1e1) The Jensen study cites this Chowdhury study which cites, amusingly enough, one of those non-sourced government proclamations from my last post, as well as “Unpublished studies from our laboratory”. Their model is convincing enough: nicotine activates certain signaling pathways which starts a cascade effect causing out of control cell proliferation (aka cancer). But the first domino in that chain is literally “trust me, bro” with no published experimental data.
Side note: see how incestuous this all is? We have a study of studies (NIH) referencing a study of studies (Jensen) referencing a study of studies (Chowdhury), referencing…nothing at all. It’s actually weirdly analogous to cancer itself, or maybe I’m just seeing cancer everywhere by now.
1f) liver cancer. This section admits “there is limited information” and has to resort to using the old “smoking/nicotine” trick.
I told you this shit requires a lot of digging. The NIH study-of-studies has 8 different papers it references, just in the “nicotine causes cancer” section. It’s a lot of work to wade through.
Who cares? Nicotine isn’t harmful.
Yes, it is, specially at a young age…
And for pregnant people. Which is why it’s great we ban vaping and all other nicotine for young children. But by the late teens, it’s not really more harmful than coffee or carbs or weed, to say nothing of alcohol.
But is it more harmful than inhaling all the other garbage in cigarettes? It becomes an issue of damage mitigation because no amount of laws are ever able to stop substance use. They often make the problem worse, too.
Of course not, cigarettes are nasty. But what I would like to understand is: are kids vaping way more nicotine now and getting every more addicted? You don’t get addicted to cigarettes per se, but to nicotine.
And flavoured cigarettes were banned in many places and helped stop some young people from starting to smoke.
I remember the flavor ban and thought to myself that it was going to be good to do so that it would not be as attractive to kids. The article is implying that the flavor ban did not stop kids from vaping. In fact, the ban corresponded with a slight increase in kids vaping, which does not make sense to me.
Of course, correlation does not mean causation and the two facts may not be directly related. Maybe kids heard all the talk of the ban and that served as advertising to get them to start. More studies are needed.
I read a study that cigarettes also contain MAOIs. The MAOI dramatically increase the dopamine response from nicotine based on “desire”.
This could influence the perceived potency vs the measured potency.
Interesting. Gotta look into that.
Here are the ones I am recalling from. I ended up finding them
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872813/
https://www.nature.com/articles/npp201636
It’s a moral failing to be addicted to anything you rotten son of a bitch. /s
When doctors ask if you smoke, they primarily care if you smoke things containing nicotine. Iirc, that’s the cause of the smoking related heart disease risk (among other health concerns).
The vast, vast majority of the problems associated with smoking is from the carcinogens in tobacco. Nicotine can cause issues, but only on the order of caffeine. It’s a massive difference in scale.
I can’t be arsed to look up any actual research at the moment, but if you wanted to provide some, I’d be appreciative.
Is it the fins that use snuss that is showing to be much less dangerous? Basically nicotine by itself doesn’t appear to be showing anywhere near the health issue that smoking does. But idk in this world of corporate sponsored studies maybe I’ve been lied to.
I’d actually be happy to, but it requires some deep diving into studies. Most studies will have a headline that says something like “using nicotine is just as bad as vaping!!!” but the data almost never actually supports the conclusion. It’s terrible, terrible science and it’s one of the worst examples of systemic problems with bad science. There’s a clear cultural push to villify nicotine.
Then those conclusions are reported by other meta studies etc etc
I’m not saying to get your data from sketchy YouTube videos or anything, just do a critical peer analysis of the actual data from various studies. I’ll do it for you. I’ve dived into it before and I’ll be glad to do so again, but I won’t have time until the weekend. It’ll take a couple of hours. I’m gonna favorite your comment so I can get back to it.
Ok let me just lead with, how the FUCK is there no way to sort inbox replies by saved? Isn’t that the whole damn point?
Alright, here we go. Gonna have to split this into multiple posts. Here’s the first.
Let’s start, like any good research, with the wikipedia article on nicotine. The intro specifically notes how it’s NOT a carcinogen, and mentions a few extremely mild or disputed adverse effects, but doesn’t go too much into it.
Later in the article, it says
Which should be a good indicator that the common ideas about nicotine being harmful are wrong. But, fair enough wikipedia is not a stringent source and shouldn’t be taken at face value, so let’s dive deeper.
Here’s a search for “nicotine harmful effects”. Let’s separate them into broadly 3 categories of results. There’s stuff like this heart.org result, which exclusively talk about “smoking and nicotine”. These types of articles are dangerous in and of themselves because they require a level of critical thinking to separate out “smoking” and “nicotine”. A lot of anti-vaping hit pieces have a top-level title talking about nicotine, but then the body of the article references negative effects that are exclusive to smoking. Here’s one such hit piece, run by a dystopian-sounding group called the “Truth Initiative” which should immediately make anyone suspicious of their goals. Note the article is under topic “harmful effects of tobacco”, subtopic “nicotine addiction”.
Second, we have government pages like the CDC which very clearly state
I’ll spend the next few paragraphs pointing out how this is simply declared to be so by governments, with no sources whatsoever to back it up. It’s a self-referential kind of contagion of an idea being spread from government office to government office, officially by policy and unofficially by encouragement, peer pressure, and referencing other authoritative offices.
Many government pages actually have no sources listed at all; their pages are literally just political opinion dressed up in an authoritative government voice. I gave the example of the CDC because it actually does have sources: this one which just links to the home page of a different CDC department, and this one which links to an office that works on tobacco, not e-cigarette, dangers.
If you dig a bit deeper on the first page, you find this factsheet for states. Let’s take California as an example. Under the section “Public Health Response to Tobacco Use in California”, it proudly lists these accomplishments:
Emphasis mine. Note the lumping together. Again, vaping is just declared, by fiat, to be equally bad as smoking. DEFINED e-cigarettes as a tobacco product.
So far we’ve talked about two of the 3 categories, non-profits and government agencies, both of whom say “nicotine bad” with no supporting data at all. So let’s get to the 3rd category: the actual fucking data.
Let’s look at one of the top results, from the NIH. The introduction starts with the sentence “Tobacco is the leading cause of preventable cancers.” Oof, not a good sign. But let’s continue.
Oh yeah? Let’s look at these studies.
Jensen et al, “Mechanisms for nicotine in the development and progression of gastrointestinal cancers”. This is another “study of studies”. Note we’re two layers deep here and still haven’t seen the actual data. The Jensen study focuses on the mechanisms that nicotine can cause cancer, but doesn’t disclose the crucial data about dosage and likelihood. But it does reference other studies. Let’s go deeper. .
1a) Tun et al, “Tobacco use and cancer: an epidemiologic perspective for geneticists”. The Jensen article claims, “There is increasing evidence that nicotine and its derivatives activate and promote key processes in the carcinogenesis of GI cancers.” and references the Tun study. The Tun study states in the Abstract:
FUCKING TOBACCO, NOT NICOTINE. AGAIN.
1b) In the section “Role of nicotine in esophageal and oral cancer”, the Jensen study references several different studies.
1b1)Arredondo et al, “A Receptor-Mediated Mechanism of Nicotine Toxicity in Oral Keratinocytes”: studied possible carcinogenic effects on the skin, mouth, and digestive tract. Studied by incubating human cells in a culture of nicotine, and also by exposing rats to a constant exposure of pure nicotine in water (as well as a different group exposed to cigarette smoke). This is a constant, 24/7 exposure to the equivalent level of nicotine from secondhand smoke from 1 cigarette / 8 minutes for three weeks. As the Materials and Methods section says, “This concentration of sidestream cigarette smoke was selected because it represents a high ambient level that individuals could encounter at home or in other settings where smoking occurs”. It’s a study that tests the secondhand smoke affects of ambient nicotine. The incubated cells were exposed to “10 μM of pure Nic” which is the equivalent of each tiny little cell culture puffing on two cigarettes (10 kilamoles = 1.6224 mg of nic, average cigarette contains about 8.4 mg of nic, source) Best data I can find is that a pack-a-day smoker and a high-concentrate vape user consume about the same levels of nicotine as each other. But vape clouds produce almost undetectable amounts of “secondhand nicotine”, so it’s not directly comparable. The rats who drank the pure nicotine also were given doses of 10 μM (again, equal to about 2 cigarettes worth) constantly for 3 weeks.
Basically, way more nicotine than the typical vaper will encounter, only generates some indicators for some cells to possibly malform. It’s demonstration that at extremely high concentrations, nicotine can generate a mechanism for cancer.
1b2) Zong et al, “Nicotine enhances migration and invasion of human esophageal squamous carcinoma cells which is inhibited by nimesulide”: treats cells with 10x-20x the concentration of nicotine as above. Not even worth considering in the context of vaping. It’s a proof-of-concept study to show that nicotine at some level can have these effects, trusting to future studies to dial it in to levels commensurate with smoking/vaping.
1b3) Nguyen et al, “Choline Acetyltransferase, Acetylcholinesterase, and Nicotinic Acetylcholine Receptors of Human Gingival and Esophageal Epithelia”: paywalled, couldn’t bypass. Appears to be similar study as 1b1 but observing different reactions. No word on dosage in abstract.
1c) Discusses gastric cancer. Most of these studies are too paywalled.
1c1) Yang et al, “The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study”.: exclusively studies cigarette smoking.
1c2) Kita et al, “Expression of uPAR mRNA in peripheral blood is a favourite marker for metastasis in gastric cancer cases”: this study doesn’t directly deal with nicotine, but with a certain marker whose prevalence could help metastasize gastric cancers. The reasoning of the Jensen study is that since nicotine increases the prevalence of this marker, nicotine use could contribute to carcinogenic effects. (funny enough the Jensen study then cites another paywalled study whose abstract, at least, does not even mention this particular marker)
1d) Discusses colon cancer.
1d1) Wong et al, “Nicotine promotes cell proliferation via α7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells”: also geared towards cigarette smokers, but investigates nicotine independently. Mostly paywalled, with snippets available. One of the snippets references a dose of 1 μM stimulating adrenaline production, which can lead to increased cancer risk. 1 μM is a significant enough dose for regular vape users, but it’s still several steps removed (nicotine can increase adrenaline, adrenaline can increase cancer risk). Unfortunately, the methods and details part is all paywalled.
1d2) Wong et al (same Wong), “Nicotine Promotes Colon Tumor Growth and Angiogenesis through β-Adrenergic Activation”: similar line of investigation. Mice were implanted with tumors, and then fed nicotine-laden water at different concentrations. More nicotine --> more adrenaline --> bigger tumors. Note: the amount of nicotine used was supposedly consistent with previous studies showing concentrations of nicotine in typical smokers, but since mice drink about 5.8 ml of water a day and these guys were delivering either 50 or 200 mg of nicotine per ml, that’s 290 or 1160 mg of nicotine–the equivalent of either six or 24 cigarettes per day…FOR A MOUSE. In fact, the study they linked to support their claim that they’re using levels of nicotine consistent with typical smokers, while paywalled, has an excellent abstract stating that a nicotine patch of 44 mg a DAY was equivalent to the nicotine consumption of a >30 cigs/day smoker. That’s a lot lower than the 8.4mg noted in my source above in 1b1, which should suggest 252 mg of nicotine, but either way, it’s an absurd dose to give to a mouse.
So like, they took the high end of that study they referenced, increased it a little, used that as the low end of their study, made their high end 4 times that, and then gave that amount to a fucking mouse injected with a human tumor. And then did it again, 5 more times a day. And then said that “mimicked the daily intakes of cigarettes in smokers”. HAH.
1e) Pancreatic cancer. Most of this deals with models and potential modes of carcinogenity from nicotine, not hard data. But we can breadcrumb our way from the models to actual studies.
1e1) The Jensen study cites this Chowdhury study which cites, amusingly enough, one of those non-sourced government proclamations from my last post, as well as “Unpublished studies from our laboratory”. Their model is convincing enough: nicotine activates certain signaling pathways which starts a cascade effect causing out of control cell proliferation (aka cancer). But the first domino in that chain is literally “trust me, bro” with no published experimental data.
Side note: see how incestuous this all is? We have a study of studies (NIH) referencing a study of studies (Jensen) referencing a study of studies (Chowdhury), referencing…nothing at all. It’s actually weirdly analogous to cancer itself, or maybe I’m just seeing cancer everywhere by now.
1f) liver cancer. This section admits “there is limited information” and has to resort to using the old “smoking/nicotine” trick.
I told you this shit requires a lot of digging. The NIH study-of-studies has 8 different papers it references, just in the “nicotine causes cancer” section. It’s a lot of work to wade through.