For me it’s Corner Gas. I still think it’s pretty funny and there’s a decent amount of references to Canadian stuff but not enough to be off-putting. I feel like an American wouldn’t be confused watching it even if some of the references get a bit dated overtime.
I have only seen a bit of the animated version in waiting rooms.
I’m probably showing my age but I can’t believe no-one has mentioned Degrassi Junior High and Degrassi High. I grew up with Joey, Wheels, Snake, Spike, Stephanie etc. Looking back, that was a pretty hard-hitting show aimed at teenagers.