“Ascended with the Amulet” with 23 Potions of Healing (one of which is Sunfruit) + three challenges enabled. These challenges are Badder Bosses, On Diet and Into Darkness.
I played Sniper.
(Here is the Dungeon Seed: MWY-LMV-DCF. This is an extremely good seed where you can find a Dirk (not cursed) with Vampiric enchantment. This is why I still use a tier-2 melee weapon in the Demon Halls, haha).
With warlock+RoW I don’t think there is a limit to how many you can get, that could be a fun challenge