Climbing into his backyard jacuzzi that overlooked the Santa Monica Mountains, Matthew Perry uttered the seven words that would ultimately lead to his death: “Shoot me up with a big one.”

The big one, court documents would later reveal, was a dose of ketamine, a prescription anaesthetic and a hallucinogen that has become popular for its off-label uses to treat depression and anxiety. It was the actor’s third injection of the day.

Hours after that fatal dose, the “Friends” actor was found face down in the jacuzzi. Medics pronounced him dead at the scene with a coroner finding ketamine was his primary cause of death.

The details about Perry’s last day alive on 28 October 2023 were revealed in court documents following a police probe that ultimately led to five people being charged in relation to his death.

The documents offer an in-depth look by the law enforcement agencies into his drug addiction, which he struggled with for decades, and a glimpse into Hollywood’s ketamine drug network. Doctors and experts told the BBC the growth in ketamine’s popularity in recent years has caused the market to explode, with the expansion of ketamine clinics and online services offering easy prescription access to the drug, as well as a burgeoning illicit drug market.

“It’s super easy [to get], - be it underground or prescription,” Dr David Mahjoubi, who serves as president of the American Board of Ketamine Physicians, told the BBC. “I have celebrities that are getting a prescription from me. It’s super easy, not hard at all.”

  • @graeghos_714
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    818 days ago

    I have friends taking it through the therapy groups and it’s pretty concerning to me. Self control is not high on their list of skills

    • @BonesOfTheMoon
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      318 days ago

      I have a friend doing it through a clinic for depression. Doesn’t seem to have helped from what she says.

      • @theilleists
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        1218 days ago

        I’ve got the daily low-dose version, and it’s changed my life. True to expectation from a dissociative drug, it causes me not to feel so much personal identification with the unwanted thoughts that keep bubbling up in my head. It may not work for everyone, but it works for me.

      • @[email protected]
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        18 days ago

        I have a MDD diagnosis and when I tried MDMA, I felt ‘normal’ for about a week after the acute effects wore off. I hear they’ve been trying MDMA in PTSD trials and I hope they do depression too. Difference was night and day, and If that stuff wasn’t HORRIBLE for your heart I may have tried self medicating in smaller doses.

        • @[email protected]
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          18 days ago

          Interesting. I also have MDD (or bipolar 2, they’re not sure) and had the same outcome after MDMA.

          Yet, I am afraid to use it on the regular basis not only because of legal status, but also because of some rumours that MDMA is toxic to neurons.

          • @[email protected]
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            218 days ago

            All I know is if they find some kind of treatment where the risks are well defined and similar to other drugs on the market I’m on board.