The rule could be anything, as funny or as serious as you want. The universe will progress in a similar way that it has up until this point, unless your changed rule prevented it from doing so.
Some examples might be:
- The invention of currency is not allowed.
- Iron is slightly less stable.
- The Ancient Greeks are able to cultivate Silphium, which does not go extinct now.
Remove every soul that would ever become a parasite 1%, or a Wiccan. Both rotten to the core.
What’s wrong with Wiccans? I know a few, they’re fine people.
A lot of them are assholes in one way or another, at about the same distribution of every other social group