At the end of the day, they’re just different ways of reaching the same goal: universal packages for Linux. I personally use them interchangeably depending on the application and use case.

There are some packages that definitely work better and are intended to be used and installed via your native package manager (if they rely on system libraries and whatnot). But using either a Flatpak or AppImage results in the same experience - in my experience. It’s a personal preference.