Scientists are learning more about how psychedelic mushrooms may alter the brain, potentially leading to long-lasting reversals of depression, anxiety, cluster headaches and more.

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    19 days ago

    from the article:

    And it’s that disorganization that is ultimately therapeutic, according to Nutt: “Depressed people are continually self-critical, and they keep ruminating, going over and over the same negative, anxious or fearful thoughts.

    ↑ That’s actually what psilocybin causes me to do, sometimes.

    “Psychedelics disrupt that, which is why people can suddenly see a way out of their depression during the trip,” he added. “Critical thoughts are easier to control, and thinking is more flexible. That’s why the drug is an effective treatment for depression.”

    I would not group all psychedelics like that. For me, psilocybin specifically often causes me to revisit terrible moments in my past and dwell on those thoughts in a way that amplifies depression. Other psychedelics put me in the moment and have no such risk of dwelling on the past.

    Small clinical trials have shown that one or two doses of psilocybin, given in a therapeutic setting, can make dramatic and long-lasting changes in people suffering from treatment-resistant major depressive disorder, which typically does not respond to traditional antidepressants.

    Emphasis mine. I must say a therapeutic setting is very important. Don’t try psilocybin alone if you have negative events in your history. But also have to say it’s a game of chance. If there is just the right amount of stimulation around you, so you are not alone but also not so chaotic that you introvert to introspect as if alone, then psilocybin can be extremely fulfilling.