Maybe a different religion, or especially political beliefs seems to be a big deal-breaker. Do you still find it worthwhile to keep them in your life?
I do. I have e.g. Christian Conservative friends, and Atheist Liberal ones, etc. I enjoy each one for what they are. I mean, nobody is perfect! (like me 😁)
I think it’s probably better that way. If you isolate yourself from people who are different it becomes easier to view them as “other” and be more willing to support harms to them.