They are related drugs with similar profiles, but they are not the same drug. Vyvanse is Lisdexamfetamine, which is a pro-drug, that your body converts into dextroamphetamine. This can have a big impact on some people, either making the drugs more or less tolerable. Actual metabolic rates for drugs can be significantly different from person to person.
They are not the same drug, reread what I said. You can’t be very familiar with pharmacology if you don’t understand prodrugs. They turn into almost Adderall, which isn’t straight dextroamphetamine. This changes how they effect the body, you can say “essentially the same” all you want, but it’s not true when it comes to how they actually impact people. Differing metabolic rates due to naturally different levels of metabolizing enzymes causes prodrugs to have more variance in their peak blood serum levels, it causes later onset of effect and can cause large variance in duration of effect. This can be very helpful or even dangerous for some people. They are not perfectly interchangeable, even if most people find them pretty similar.
Thank you. Adderall (amphetamine + dextroamphetamine) gave me intolerable side-effects at the minimum effective dose for me. That’s my doctor moved me to dextroamphetamine, which has been lovely. They are not the same.
Unrelated comment: I’m interested in following this exchange, but it’s collapsed, dunno if the pic embeds here or what. I click, jerboa crashes, rinse and repeat. I dunno, just felt like talking about. Dunno if anyone else has had similar dysfunction.
Adderall and Vyvanse are essentially the same drug. You’re on both?
They are related drugs with similar profiles, but they are not the same drug. Vyvanse is Lisdexamfetamine, which is a pro-drug, that your body converts into dextroamphetamine. This can have a big impact on some people, either making the drugs more or less tolerable. Actual metabolic rates for drugs can be significantly different from person to person.
Yes, but Adderall is dextroamphetamine, the drug Vyvanse turns into.
I’m familiar with the pharmacology and their respective mechanisms, just stating that they’re essentially the same drug
They are not the same drug, reread what I said. You can’t be very familiar with pharmacology if you don’t understand prodrugs. They turn into almost Adderall, which isn’t straight dextroamphetamine. This changes how they effect the body, you can say “essentially the same” all you want, but it’s not true when it comes to how they actually impact people. Differing metabolic rates due to naturally different levels of metabolizing enzymes causes prodrugs to have more variance in their peak blood serum levels, it causes later onset of effect and can cause large variance in duration of effect. This can be very helpful or even dangerous for some people. They are not perfectly interchangeable, even if most people find them pretty similar.
Thank you. Adderall (amphetamine + dextroamphetamine) gave me intolerable side-effects at the minimum effective dose for me. That’s my doctor moved me to dextroamphetamine, which has been lovely. They are not the same.
Unrelated comment: I’m interested in following this exchange, but it’s collapsed, dunno if the pic embeds here or what. I click, jerboa crashes, rinse and repeat. I dunno, just felt like talking about. Dunno if anyone else has had similar dysfunction.
I’m on Connect not having a problem.
I’m just using Lemmy on Firefox mobile. Jerboa became too unstable for me and this so far has worked the best imo.
Try liftoff.
Yup. Adderall alone was too much, Vyvanse alone was too little. A max dosage of one and a smidge if the other during the middle of the day if needed?
Just right.
Edit: to go with what the other person said - my metabolism is really fast and I typically run “hot.”
Interesting approach. I myself use a non -stimulant (atomoxetine) daily with a supplement of Adderall as needed