Sure, you could have ran RotT in a number of sourceports, DOSBox, or even a virtual machine if you were determined, but the experience of getting it up and running on a modern system hasn’t been great.
Nightdive released Ludicrous Edition and it’s finally accessible enough to just launch and play. Includes midi and 2013 soundtracks, all the original episodes, plus one new one, and a couple of qol adjustments in the menus.
I think ROTT was one of the games included in various retropie builds (the engine, you’d still need the data files for the non-shareware stuff).
I wonder if they’ll also include support for the updated version in the future.
Most of what I remember of the game was blowing people up and watching an eyeball go flying by, or the “hand of God” weapon