A new synthetic opioid, cychlorphine, is emerging in illicit drug markets and forensic labs, raising fresh concerns for public health and law enforcement. Its distinct chemistry and ease of synthesis make it harder to track, underscoring how prohibition continues to drive the evolution of more potent and unpredictable drugs.
If you are arguing for harm reduction I agree completely. The problem was that opioid use exploded because of over prescribing being driven by greedy corporations and regulatory capture.
A certain percentage of society is known as opioid responders. They have a very overwhelming experience when given opioids which can lead quickly to dependence and a life-long drug disorder. You can’t put the cat back into the bag so to speak which is why over prescribing caused an epidemic.
You are correct that the feds clamping down on opioid prescribing caused the lethality to increase due to a shift from the legal to illegal markets hence the need for harm reduction. Every opioid death is preventable.