Link to study: American Academy of Neurology
After adjusting for factors such as age, sex and race, as well as health-related factors such as high blood pressure and diabetes, researchers found people who had been taking acid reflux drugs for more than 4.4 years had a 33% higher risk of developing dementia than people who never took the drugs.
The papers under discussion:
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study
https://n.neurology.org/content/early/2023/08/09/WNL.0000000000207747
Association of Proton Pump Inhibitor Use With Incident Dementia and Cognitive Decline in Older Adults: A Prospective Cohort Study
https://www.gastrojournal.org/article/S0016-5085%2823%2900873-9/fulltext
Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
https://pubmed.ncbi.nlm.nih.gov/31152740/