I think the answer here depends on your friend group and what you’re actually excited to play. I think you’re more likely to have fun if you’re playing something compelling than if you’re playing something that’s “easier”. Then it comes down to how good the learner’s resources are.

For me and my friends, I think diving into traditional Fantasy was great.

For systems and content, I can speak to the PF2e Beginners Box, which is effectively playable by players and GM with 0 prep for anyone, even completely new players (that’s why it exists). That system is fairly"crunchy", but there are lots of resources online and many VTTs handle the tedium for you. D&D5e is also somewhat beginner friendly, but not as much for a new GM (you’ll have to prep yourself a lot beforehand). I’ve easily run games for completely new players with minimal issues, but as a new GM it could be overwhelming. There are other systems that are much less rules-heavy, like PBTA or Blades in the Dark. I’ve got a game set to start for Blades, but we haven’t had our first session yet, so I can’t comment.

Good luck and enjoy! Remember the point is to have fun, first and foremost.