For example, the Prior plague, would we need offworld or off-reality contacts to be able to deal with it, or is modern medicine up to the task, with mRNA vaccines and CRISPR?

It took an alien modified by interdimensional beings to cure it initially. But once they could observe an antibody they were able to manufacture the vaccine. With more outside help, but apparently without alien materials.

Testing if I can post from lemmy to kbin.