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  • Chetzemoka
    2•1 year ago

    Hahaha, I love working with older folks. They’re my favorite patients.

        • @cheese_greaterOP
          2•1 year ago

          I gotta sleep soon aha but I’ll leave you with a last question for tonight: what do you think mediates Apigenin’s efficacy for sleep? Like what is the mechanism behind its efficacy, what systems does it modulate?

          Thanks and no rush, I’ll listen to that article tomorrow :)

          • Chetzemoka
            2•1 year ago

            So, it’s interesting, because it’s well-known to have effects on the same GABA receptors as benzodiazepines (like Xanax), but none of the addictive, physical dependence problems, and apigenin doesn’t respond consistently to the drug we use to reverse benzos (called flumazenil).

            So… we’re not entirely sure? It could still be the GABA effects that help with sleep. But there’s also a host of antiinflammatory neurological effects that probably better explain its efficacy against Alzheimer’s, for example.

            Now, if you really want to put yourself to sleep, feel free to crawl through this alphabet soup of a research article lol:

            https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/

            • @cheese_greaterOP
              2•1 year ago

              Thanks and I will check those out. Does the flumazenil displace GABA_B ligands/receptors as well or only _A?

              Thats all for tonight, night

              • Chetzemoka
                2•1 year ago

                Oh you’re getting in the weeds now hahaha. Looks like it’s primarily GABA_A

                https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326685/

                I just had to look that shit up haha. I’ve never thought to check into it beyond just “you’re not breathing, so I’m about to make you very angry by reversing your high, sorry bro” lol

                • @cheese_greaterOP
                  2•1 year ago

                  It seems as if _B ligands are both way less ubiquitous and also variably less-reinforcing than traditional alcohol-type sedatives like benzos/barbs/sleeps, although I say that very conjecturally (is that a word? Aha). And less likely to be overdone to the point the therapeutic window is being dangerously exceeded or a polypharmacy situation that leads to medical emergency like that

                  From my own experience with baclofen which I used to wean off drinking and help with the induced anxiety, I didn’t really find it super pleasent or enjoyable and there were enough annoying sides like tearing up and a crappy fuzziness that was super offputting. Alcohol and sedatives (especially sleeping pills), totes different story (I find them as a class GABA_A way more dangerous and mindlessly compulsive.

                  • Chetzemoka
                    2•1 year ago

                    Huh, now that’s super interesting.

                    Ok you and I both have to go to sleep, but now you’ve got me wondering about the eternal debate amongst our medical residents about benzos vs. barbiturates for acute alcohol withdrawal. I’ll have to read up on this some more

      • Chetzemoka
        2•1 year ago

        Literally the only thing that gives me refreshing sleep. (See also: mitochondrial dysfunction that I mentioned in my other comment about CQ10.) Apigenin seems to improve what’s called “sleep architecture” in a way that none of the pharmaceuticals I’ve ever tried do.

        • @cheese_greaterOP
          2•1 year ago

          Shit, I may have to try it first. Im getting other sleep stuff done but every bit helps