• @jeffw
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    edit-2
    10 months ago

    Notably, none of the trials in this review sampled clinical populations, although one paper included participants with high but subclinical depression symptomatology.

    The present review indicates that doses of 10 μg and above yield detectable subjective effects, raising the possibility that expectancies stemming from these effects contribute to the overall responses

    This basically says that, among young educated people, getting high is fun. The effects could be largely from expectations. There’s nothing here about clinical benefit of microdosing. It also says higher doses are better. Then why not focus on higher dosages that we know have significant psychological effects? There’s really little good evidence on microdosing. Most of the good studies don’t suggest benefits anywhere close to threshold doses.