- stultify - deprive of strength or efficiency; make useless or worthless
- sessile - permanently attached to a substrate; not free to move about
- insuperable - impossible to surmount; insurmountable
- quixotic - not sensible about practical matters; idealistic and unrealistic
- capricious - determined by chance or impulse or whim rather than by necessity or reason; impulsive; whimsical
- malevolent - having or exerting a malignant influence
- antipathy - a feeling of intense dislike
- indissoluble - incapable of being dissolved (in a solution)
- inexpert - lack of professional skill or expertise
The Bicentennial Man and Other Stories by Isaac Asimov
Short story: That Thou Art Mindful of Him
Stultify and Sessile sound like DnD spells that do exactly what their definition is.