In a first, researchers were able to compare records of people who drank polluted water in Veneto, Italy, with neighbors who did not

For the first time, researchers have formally shown that exposure to toxic PFAS increases the likelihood of death by cardiovascular disease, adding a new level of concern to the controversial chemicals’ wide use.

The findings are especially significant because proving an association with death by chemical exposure is difficult, but researchers were able to establish it by reviewing death records from northern Italy’s Veneto region, where many residents for decades drank water highly contaminated with PFAS, also called “forever chemicals”.

Records further showed an increased likelihood of death from several cancers, but stopped short of establishing a formal association because of other factors.