• I'm back on my BS 🤪
    link
    fedilink
    English
    404 months ago

    If mice ever become the dominant species, they’re going to start off so overpowered with advancements in medical treatments.

  • @[email protected]
    link
    fedilink
    214 months ago

    I’m convinced that the Alzheimer’s field is one of the areas of research that will be looked back upon with disillusionment.
    Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer’s disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

    • @[email protected]
      link
      fedilink
      254 months ago

      All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

      • @[email protected]
        link
        fedilink
        84 months ago

        TIL. Damn.

        Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.

    • @joelthelion
      link
      24 months ago

      How do you explain that amyloid-targetting therapies are seeing some success, even if limited?

  • srasmus
    link
    English
    214 months ago

    I feel like I’ve heard that clearing the tangles really doesn’t affect the trajectory of the disease?

    • @SuperIce
      link
      English
      274 months ago

      Yeah, from the article “while many tau-based therapies show promise in animal models, their translation into effective medicine for humans ‘has so far failed.’”.

  • SineSwiper
    link
    fedilink
    English
    74 months ago

    Well, I’m certainly glad there a nasal spray that deals with the toxic mice tangles in my nose.