Although WUI fire emissions are small relative to total fire emissions, the health impacts of WUI fire emissions are disproportionately large due to the proximity to human settlement. Here, we looked at PM2.5- and O3-related health impacts. At the global scale, the fraction of WUI fire–induced APDs to all fire–induced APD is about three times the fraction of WUI fire emissions to all fire emissions. Over WUI and urban regions, WUI fires tend to have a larger contribution to APD compared to other areas.