I've gone on record saying that Mewgenics is, in a lot of ways, a sequel to The Binding of Isaac, but not in any of the traditional ways. This confuses many. So, I'm going to attempt to break down why, in many ways, Mew is a successor to Isaac and the things I think I failed at with Isaac that I'm improving upon with Mewgenics!
Edmund McMillen talks about how the upcoming game Mewgenics compares to Isaac.