If the studies were done primarily on people with sleep problems, then the reduction in pain could easily be explained by getting better rest due to the melatonin, not directly from the melatonin itself.
Or the other way around. A lot of people cannot sleep because they are suffering from pain.
A LOT of open questions, but sounds promising for people with long term, chronic pain.
Especially if it helps with both sleep and pain.
Chronic muscle pain or sleep paralysis, weird dreams and a day of general grogginess?
My thighs have already been sore for a few days, they can take it a bit longer.
That sounds like a dose too high
Try something like 1mg or less slow release
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There’s nothing wrong with using it every night if indicated, the safety profile is excellent
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Firstly, I assume you mean down regulated and not up regulated
Secondly, this is the same as practically every receptor binding drug consumed at high doses
There is no reason to take melatonin at high doses, in fact, the dose response curve drops off and make high dose melatonin less effective than low dose melatonin
1mg or less slow release seems to be the ideal in research, and research has cleared the safety for up to a year of continuous use at which point there might be cardiovascular concerns in severe insomniacs - but the research is poor quality and full of holes to the point where the authors themselves are dubious of the correlation and call for more research
