Key Points

Question Are puberty blockers associated with lower odds of diagnosed mood disorders and suicidal thoughts and behaviors for transgender compared with cisgender youths?

Findings In this cohort study among 231 783 youths identified in claims data, prescription of a puberty blocker was associated with decreased adjusted odds of mood disorder and suicidal thoughts and behavior diagnoses for transgender youths compared with cisgender youths.

Meaning In this study, puberty blocker prescription was associated with partial attenuation of mental health disparities for transgender youths, suggesting mental health benefits.