In a world first, Harvard biologists worked with Google to diagram a cubic millimeter of human cerebral cortex at the subcellular level, paving the way for the next generation of brain science.

In 2014, a woman undergoing surgery for epilepsy had a tiny chunk of her cerebral cortex removed. This cubic millimeter of tissue has allowed Harvard and Google researchers to produce the most detailed wiring diagram of the human brain that the world has ever seen.

Biologists and machine-learning experts spent 10 years building an interactive map of the brain tissue, which contains approximately 57,000 cells and 150 million synapses. It shows cells that wrap around themselves, pairs of cells that seem mirrored, and egg-shaped “objects” that, according to the research, defy categorization. This mind-blowingly complex diagram is expected to help drive forward scientific research, from understanding human neural circuits to potential treatments for disorders.

  • @AbouBenAdhemEnglish
    7•4 months ago

    This cubic millimeter of tissue has allowed Harvard and Google researchers to produce the most detailed wiring diagram of the human brain that the world has ever seen. […] This helped researchers to identify the brain’s six cortical layers and white matter.

    I thought the human cerebral cortex was two to four millimeters thick—how does a single cubic millimeter contain all six layers plus the underlying white matter?