Critics warn new medicines could be lost by reducing out-of-pocket costs. But there are good reasons to be optimistic about future medical research.

It is a harrowing proposition: that in trying to control drug prices for 67 million Medicare patients now, we might inadvertently prevent the development of future drugs that could save lives. Implied, if not stated outright, is that we’re putting a cure for cancer or Alzheimer’s or some other intractable disease in jeopardy.

But we have good reasons to believe that the current policy won’t have such a trade-off any time soon. For one, pharma is hugely profitable, and these negotiated prices, while potentially chipping away at profit margins, should hardly entirely dampen the incentive to innovate, according to a couple of key studies of the industry. Two, if we are worried about future innovation, we should be focused on making it cheaper to develop drugs – and this is actually one area where AI is showing promise. By identifying the best candidates for possible treatments early in the research process, we could speed up development and continue to reduce costs — without losing out on tomorrow’s breakthroughs. …

  • @FlowVoidEnglish
    8•3 months ago

    They aren’t wholly theorized and funded by the government.

    By far the most expensive step of drug development is the phase 3 clinical trial, the final stage before a drug can be released. The government doesn’t fund those at all. Government mostly funds pre-clinical trials (ie in animals or tissue culture) which are way cheaper.

    The average government grant for a biomed research proposal is nearly $600,000.

    The average phase 3 clinical trial costs $20 million.

      • @FlowVoidEnglish
        4•3 months ago

        Government-funded research is typically basic science research. It results in general knowledge that is usable by anyone, ie it does not support a specific product. No pharma company will pay for something that helps competitors as much (or possibly more) than it helps them.

        For example, government-funded research showed how injected mRNA could be directly absorbed and expressed by human cells in tissue culture. That remarkable discovery can be used by any pharma company to make a product. So pharma companies started developing various mRNA vaccines, and testing them in humans (Moderna, Pfizer, etc). But no pharma company would have funded the initial research that showed this was possible.

        • @[email protected]English
          2•3 months ago

          Thanks for weighing in. Is there somewhere I can learn more about this? Big Pharma getting rich off tax payer funded research is an often repeated claim on internet forums, and I’d like to educate myself some more on this topic. Thanks!

          • @FlowVoidEnglish
            2•3 months ago

            In general, I think “Big Pharma gets rich off taxpayer funded research” is kind of like “Ford gets rich off taxpayer funded roads” or “Apple gets rich from taxpayer funded schools”. They are true in one sense, but that doesn’t mean those companies would pay for those things. That’s why government ends up paying for common goods.

            Note that “Big Pharma gets rich off taxpayer funded research” is different from “Big Pharma charges more than necessary to cover its own research costs.” You can find a pretty good analysis of those costs here.