It’s really situational depending how much you value the skip prize and what jokers you have.

Skipping is more valuable when:

• (like you said) you have a joker that triggers off of skipping like throwback
• you have jokers that decay like ice cream or turtle bean
• the prize is especially valuable to your build eg. a mega standard pack when you have Hologram
• you’re past white stake and it’s the small blind which now gives no base reward money

Skipping is less valuable when:

• you have a ton of money you could spend on stuff (not if you’re trying to build up a lot of money for bootstraps/bull)
• You have Jokers that build up while playing like Spare Trousers and Burned Joker
• You have Jokers that trigger when you select a blind like Cartomancer
• You have Jokers that affect the shop like Chaos the Clown or Perkeo

IMO a lot of skips are worth it as long as you think you can handle the next challenge. Almost all of the gold rewards will give you more gold than if you fought the actual blind the doubling one has the potential to break your run and a free joker is like making money as well, especially if it’s guaranteed to be rare.

The other skips are worth it too if your deck is even slightly built for it.