I have a flatmate who is making the switch from windows 10 to linux and I Fedora is a distro that I trust to provide a good stable experience. I however use Nobara which comes with all the gaming related tweaks already done. I dont want to recomend Nobara because its package management is intuitive.
The changes i think I need to make is, remove fedora flatpak store. Enable non free software repo. Install proprietary nvidia driver. Install steam, wine, lutris, heroic store.
Is there anything that is required for a smooth Fedora gaming experience?
I am using stock Fedora for casual gaming. Most games I play have a native linux port. Just install Steam, enable Proton in the menu and you are good to go. Heroic should also come with its own Wine version preinstalled. I never had the need to setup Lutris, Bottles or a system-wide Wine install.
Depending on the games you play, using X11 over Wayland might be the biggest change needed. CS2 with AMD on Wayland stutters a lot, has mouse glitches and random crashes. With X11 the framerate is x2 higher and a lot smoother (though still a lot worse than Win10).