Yes. But it’s got to be in a quiet room with decent speakers or headphones/headset. It’s in higher pitched singing or cymbals I notice it the most. The genre of music also makes a difference.

It becomes more apparent when listening via Bluetooth because lossless is only made lossy once. Starting with lossy and then using the compression on Bluetooth audio multiplies the flaws.

And I find I have more fatigue when listening to lossy compression. It’s subtly harder to hear.