This is just historically inaccurate, while smallpox blankets were give out in a couple cases most of their population died out from new European diseases across the continent before we’d ever made contact. They spread through the environment and killed millions to the West coast before we even knew what had happened.

Add to that the fact that we decided what the value of our goods were worth in their financial system, and technology was sold to certain tribes and not others (keeping in mind that colonists weren’t coming into a unified system but integrating into a complex ecosocial dynamic where we gave advantages to specific groups) there was no way in hell they’d have a fair fight.

The truth is, the game was rigged from the start.