Santa Fe, NM has a rich history dating back to at least 900 AD. When I lived in New England, many people believed that their relatives were pioneers of civilization in North America, with ancestors that could be traced back to the 1700s. However, even by European standards, La Villa Real de la Santa Fé de San Francisco de Asís is much older than Mayflower era settlements, having been founded in 1610.
It has some other names in local languages, according to Wikipedia:
Tewa: Oghá P’o’oge, ‘white shell water place’;
Northern Tiwa: Hulp’ó’ona;
Navajo: Yootó, ‘bead + water place’
yeah, basically water place. it makes sense as there is a town 90 miles north called “NO WATER”.