I’m a therapist, and I’ve had several patients on ketamine infusions. Most had great results. One has severe treatment-resistant depression and didn’t get any relief, but that’s to be expected, not everything is going to work for 100% of people. I’ve seen wonderful transformations in people with trauma and depression on ketamine.

EDIT: You don’t have to do infusions, you can also do a sublingual tablet. The infusions are more intense from what I hear. No personal experience.