cross-posted from: https://lemmy.world/post/18671978

If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

  • @graeghos_714
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    928 days ago

    Getting T-Boned on my motorcycle when I was 62 made me real old, real fast because my mobility has been so reduced

    • @[email protected]
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      328 days ago

      Don’t give up, even if it absolutely fucking sucks. The people who give up never get it back. If you were wild enough to ride a motorcycle, you’re wild enough to invest into yourself. Because it takes guts to buy in to yourself. It’s a lot easier to just fade. I lost my mobility for a while and I fucking gave up. It made me feel like shit, and I literally spent weeks just laying in bed not really crying but feeling absolutely morose and like I had been cheated of the joy of the rest of my life. And it was fucking brutal. But I am so much more mobile and functional now than I was even a year ago and it takes so much time, effort, pain and realistic-hope (as in you can be optimistic, but also be kind to yourself and be a realist about where you are and where you’re trying to go and you’ll be a lot happier about all the small victories along the way). You might not even realize at some point how much your regained but I hope to god you find what you need and get back to some semblance of happiness.

      As for motorcycles, I am not sure I would ride them anymore nowadays because it seems like people are so brain-dead when they drive (Is it phones?) that they intentionally seem to go for folks. But safe healing, because you deserve it and even if you don’t get where you want to - don’t sell yourself short. Because that’s when stuff starts to fall apart bit by bit and I am sure you’ve still got more to live/give =)!

      • @graeghos_714
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        121 days ago

        No giving up, just dealing with reality. The Dr said my foot was squished like a grape being stepped on. I’m really happy to have a foot but the toes will never work right again. Every joint in 3 toes are fractured and the first joint in the little and adjoining toe are also fractured. Some days the pain from those fractures can be a little intense especially when I try to walk too much. Some of the little bones in the foot are also out of position especially in the heel. When that’s a problem it feels like the achilles is under extreme duress but because it’s bone related I can’t stretch it out. I do most of what I did before, just with more down days now. But as I said, so thankful I have a foot and leg still after a direct T-bone on the leg. Leaning to turn away from her probably saved the leg from the initial impact as she hit the bottom of the bike which snapped me up into her which is when the foot and leg got pinched. The foot being pinched stopped me from flying initially and that’s when the foot tore everything inside, my leg mostly had frame impact damage so I could see every frame junction on my knee and leg. Almost 2 years later the visibility of the damage hasn’t changed much. The jacket armor on the elbow and shoulder were both through the kevlar and into the armor itself so 60’ of tumbling took its toll but the armor took a large sum from that toll
        https://imgur.com/tRUZRL6 is the boot I was wearing. My foot pretty much tore where the boot tore. I think I got almost 50 stitches in the foot

  • tiredofsametab
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    428 days ago

    Actual study: https://www.nature.com/articles/s43587-024-00692-2

    We collected longitudinal biological samples from 108 participants over several years, with a median tracking period of 1.7 years and a maximum period of 6.8 years, and conducted multi-omics profiling on the samples.

    That’s not a lot of people studied for not a lot of time. It feels like the wording in the Guardian article is trying to misrepresent things.

  • @paddirn
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    428 days ago

    Oh cool, on the cusp of some dramatic aging. Getting old sucks. We should go back to the time when we all died at an early age. Civilization was a mistake.

    • @[email protected]
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      528 days ago

      There was no time where we just died at an early age. The life span of humans has not changed, Cicero’s wife Terentia lived over 100 years . History has a low life expectancy because you were more likely to die from something else than old age.

      If by going back to the time where you died of plague you can just be anti modern medicine and get the same authentic experience.

      • @[email protected]
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        28 days ago

        Also the infant mortality rate was very high for most of human history, reducing the average age of death considerably.

  • @[email protected]
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    228 days ago

    Well from personal experience I would argue that there are more than 2 points in life where you age dramatically, because never in my live I have been 44 or 60 years old, but still had at least one phase in live, where my body suddenly felt a lot older.

  • @[email protected]
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    128 days ago

    I actually think aging is really beautiful. I mean there is an element that is sad. Especially if you were a particularly youthful looking individual. But on the other hand, if people stayed the same they would look unnatural. Which I think is sort of the case for most celebrities outside of that one guy…Paul Rudd. I think he’s doing fine. But I look at people like Brad Pitt and I just see the living embodiment of a spoiled individual. Besides which, superficial things are so bogus because they are aimed exclusively towards youth. And a certain image of youth at that. And when you don’t make the grade your entire life quality typically suffers because of it.

    Now I do have to pull out a little something and wonder if this is split across the ethnicities. But I think at the end of the day I heard something like collagen being what makes “black don’t crack” and hot Asian grandmas like Tsai Chin ;D! But I have also always wondered if it’s the joy you carry in your heart. Because if you take challenges on as part of the experience of life, instead of the burden of existence I think you age more gracefully. And have seen it working with the elderly over the years. And in my own grandparents, health pending. But the ones who either laughed, or went about things with conscious intentions (I’m thinking about a very quite but hyper intelligent Slavic grandma I once helped who invited me to her place for tea. It was incredibly well cared for and she was clearly a very well read individual with what I’d consider all her faculties. But she was for sure not a “lively” or “cheerful” individual.) even if it’s rage. Just being active in your body and mind to some extent seems to slow the aging process down greatly. What seems to speed it up in my book? Being forgotten and television.

    One thing I think about often is how different our world has changed since I have been alive. And I am sure others can echo the sentiment all the way up to our oldest and youngest lot. But by that I mean we’ve seen such sweeping waves from group activities to solitary ones. Outdoors movement, towards indoors. Social niceties towards calm-socialization (as in keeping it in the “family”). I wonder what all of this is doing to us as a whole. Because I am for sure far sicker than my parents, and perhaps to an extent most of my grandparents. But I will also say I am more honest about what’s going on with my body, inside and out, than any of them ever were too.

    Hmm. Just has me have a think.

    But either way, aging is lovely even with the aches and pains because it means I am still here and I love that. I love being able to still be spinning here =)!