For a while now the transition away from Manifest V2 (MV2) to MV3 has been on-going and it looks like it is entering its final phase of deprecation, at least, in the case of Google Chrome. A recent discussion thread in the w3c WebExtensions Community Group GitHub repo has highlighted how the latest and upcoming versions of the most popular browser are expected to be its final releases with support for MV2 extensions.
What this essentially means is that the tricks and bypasses that were used to keep MV2 extensions like uBlock Origin and others alive will not work any more on Chrome, or at least not for very long. For example the Windows Registry mod that could extend MV2 availability will cease to function after Chromium version 151.
Firefox, despite all the suspicions around Mozilla, still works well, is still user friendly, privacy friendly, and well maintained. You can either pick a fork that includes a few more things, or just go with vanilla Firefox and ublockorigin. This extension alone (which is highlighted as a recommended extension on the mozilla add-ons website), on its default settings, already sets you up for most ads and privacy hostile sites.
If you want to go further you can look into noscripts, but it’s already way more involved, because it will break some sites until you look into what to allow or not.