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There was a time early in the electrification of America with Edison, he pushed for DC over AC. https://en.wikipedia.org/wiki/War_of_the_currents
The last DC utility turned off in 2007. http://www.jaygarmon.net/2010/11/in-what-year-did-last-of-new-yorks-dc.html
As far as answering your question, you can run a transformer, but new construction and new appliances will likely be built with DC service in mind.
Most things with a motor would prefer AC. Alternatively, they use DC, but it’s a brushless motor with more complicated electronics and are more expensive for it. This would apply to anything with a heat pump, which includes air conditioning and hybrid water heaters.
Things that run electric resistive heating is fine with either AC or DC, but it has to be higher voltage. The benefits of DC disappear because nothing wants to run at the same voltage.