There are some minor choke points (restorecon if installing with a “dirty home” and installing RPMFusion), but yeah, otherwise it does a great job of staying out of your way.

For me:

• remove fedora flatpak
• add flathub
• remove preinstalled bloat (especially annoying on GNOME as these apps all have weird names)
• add user to libvirt plugdev groups
• setup automatic updates is weird, packagekit sucks a bit
• Gnome software sucks, KDE Discover + Flatpak is way easier. But the flatpak backend is probably preinstalled
• add rpmfusion on KDE needs CLI poorly, but nothing unfixable
• install libavcodec-freeworld