tol is Tolerance.
HEY!!! GET OFF LEMMY AND GET HIM A 3RD SHOT!!!
Tolerance is part of the equation, but breathing and circulation play a huge role too
If a nasal spray is administered but the person isn’t breathing it will still be absorbed, but if oxygen levels are low af it’s going to take more time, therefore you keep pumping the narcan until you’re sure. When I’m standing over an OD’ing street kid, I’m taking NO chances.
Same thing with intramuscular injections. Yes the drug is in the body but circulation helps a lot and if the heart has slowed or stopped… well. You keep pumping shots of narcan until they die or come back.
Final most important is that the user or person attending may believe the user took fent, but they probably had a dangerous street concoction consisting of fent + any other number of who-knows-what. Often referred to as “down”. There’s absolutely no way to know if they need more narcan because of tolerance or something else
edit: At the end of it all, there is no way after the fact to determine what the “correct” amount of narcan was for that situation. It is highly situational and depends on many factors. The rule is if you’re not sure, more narcan, because this ain’t the time to guess wrong.
That’s pretty much exactly what I was told back when narcan first started being available easily for pain patients and such. There’s too many factors involved to piss around with trying to calculate anything in the time you have available to make it work, so you just give more and pump that damn chest.
The application of medication isn’t exact. There are many uncertain variables at play when someone is dying. It’s quite possible that its not the only reason the patient is crashing or they’ve taken what some call a ‘heroic’ dose and its simply wasn’t enough.
Yep, other conditions, other medications, who knows? And each person is unique.
As I understand narcan, it more assertively binds to the same receptors as opiods like fent, effectively blocking the body’s response.
But if it’s been long enough, the body has already reacted to enough of the first drug, so the second (narcan) can only do so much.
I’ve seen 2 doses BARELY restore stable breathing (with oxygen support). Shits crazy
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Is the patient in MODS?
